The University of Potsdam is the third largest University in the Berlin/Brandenburg area with some 21.000 students and staff. The Department of Animal Physiology (at the Institute of Biology and Biochemistry) is headed by Salim Seyfried and studies cardiovascular development, physiology and pathophysiology using the model organism zebrafish. One focus of research deals with the molecular crosstalk between myocardium and endocardium in response to physiological changes such as blood flow. They are also working with a vascular disease model for stroke, the cerebral cavernous malformations (CCM).
The group has recently completed an unbiased small molecule suppression screen using more than 5000 substances in CCM mutant worm, fish, mouse, or human endothelial cells. Systems biology-based integration of this data with whole-transcriptome profiles of worm and zebrafish CCM mutants has revealed relevant pathways and candidate targets for small molecule-based therapies. Their multi-faceted approach to understand the CCM regulatory network foreshadows novel therapeutic applications for suppressing this devastating disease in patients.
Salim Seyfried: email@example.com