2 PhD student positions in genetics of vascular diseases

The Human Genetics lab, part of the de Duve Institute in Brussels, aims to discover the genetic variations that drive human diseases. The lab uses Next Generation Sequencing (NGS) and bioinformatics to study patient samples and generates cellular and animal models to further dissect disease processes and test new therapies. It collaborates closely with clinicians and patients to provide viable and tangible knowledge-based improvements in health-care.

For the EU-MSCA-ETN project V.A. Cure, the lab invites applications for two Early Stage Researcher/PhD student positions entitled:

Identification of novel genes that cause Vascular Anomalies (ESR 1 and 2)

You will be part of a team of 14 ESRs working on the V.A. Cure project, which aims to uncover core mechanisms of initiation and maintenance of Vascular Anomalies with the final goal to establish novel therapeutic strategies. The project is funded in the frame of the EU MSCA-ITN programme.

Job description

You will work on a research project with the following objectives:

  • Identify a Vascular Anomaly-causative gene using NGS
  • Validate the effects of identified gene-mutations on function of the encoded protein in vitro
  • Identify molecular mechanisms, read-outs, and potential therapeutic targets in a cellular model of disease
  • Generate and characterize a zebrafish model of disease by gene knock-in (if gain of function)/ knock-down (if loss of function)
  • Identify genotype-phenotype correlations

You will also take part in the international training programme of the network and participate in various networking and outreach events.

Requirements

We are looking for a motivated student with a strong commitment to basic and/or translational research, who:

  • is eligible for MSCA-ETN funding, see here.
  • has a MSc degree in biology, biomedical sciences or related disciplines
  • is a team player with good communication skills

Appointment terms

The successful candidate will receive an attractive salary in accordance with MSCA regulations for Early Stage Researchers. The period of employment is 3 years. Starting date: June – October 2019.

How to apply

– Make sure you meet the qualifying requirements.

– Submit your application to info@vacure.eu by e-mail. Please send one pdf file containing:

  • A motivation letter describing your research career goals, skills and experience (cover letter)
  • Curriculum vitae
  • Grade transcripts and BSc/MSc diploma (in English or with a translation into English)
  • Two letters of recommendation or the contact information for at least 2 referees.

Deadline for submitting applications: 22 May 2019

More information

Please visit www.vacure.eu for more information on the project, the recruitment process and selection criteria. Contact for questions: Miikka.Vikkula@uclouvain.be