ESR 3

PhD student position aimed at peptide specific targeting of vascular disease lesions

The Translational Genomics Lab within AstraZeneca Discovery Sciences, IMED Biotech Unit, in Gothenburg, Sweden is a state-of-the-art molecular biology, cell biology and animal facility, driving cell and animal model work on the AstraZeneca Gothenburg site. Our labs are fully equipped to support molecular biology, in vitro and in vivo activities. In addition, through sister teams in the department, we have access to key equipment and skilled personnel including protein science, Next Generation Sequencing and assay development.

For the EU-MSCA-ETN project V.A. Cure, the lab invites applications for an Early Stage Researcher/PhD student position entitled:

Peptides for specific targeting of vascular lesions in venous malformation (VM), lymphatic malformation (LM) and arteriovenous malformation (AVM) (ESR3)

You will be part of a team of 14 ESRs working on the V.A. Cure project, which aims to uncover core mechanisms of initiation and maintenance of Vascular Anomalies with the final goal to establish novel therapeutic strategies. The project is funded in the frame of the EU MSCA-ITN programme.

Job description

You will work on a research project with the following objectives:

  • Identify novel peptides for specific targeting of lesions in mouse models of VM, LM and AVM using in vivo phage display in vitro and in vivo.
  • Characterise the binding properties of the identified peptides in mice during normal development and formation of vascular malformations and in tissue sections of human VM/LM/AVM
  • Identify and functionally characterise the target proteins.
  • Utilise the identified peptides as lesion-specific probes for detection and delivery of (cytotoxic) agents.
  • You will also take part in the international training programme of the network and participate in various networking and outreach events.

You will enrol in a PhD programme at Karolinska Institute.

Requirements

We are looking for a motivated student with a strong commitment to basic and/or translational research, who:

  • is eligible for MSCA-ETN funding, see here.
  • has a degree in biology, molecular/cell biology, biomedical sciences or related disciplines
  • is a team player with good communication skills

Appointment terms

The successful candidate will receive an attractive salary in accordance with MSCA regulations for Early Stage Researchers. The period of employment is 3 years. Starting date: June – October 2019.

How to apply

– Make sure you meet the qualifying requirements.

– Submit your application to: info@vacure.eu. Please send one pdf file containing:

  • A motivation letter describing your research career goals, skills and experience (cover letter)
  • Curriculum vitae
  • Grade transcripts and BSc/MSc diploma (in English or with a translation into English)
  • Two letters of recommendation or the contact information for at least 2 referees.

Deadline for submitting applications: 22 May 2019

More information

Please visit www.vacure.eu for more information on the project, the recruitment and selection criteria. Specific questions about the position can be addressed to john.w.wiseman@astrazeneca.com by e-mail.