ESR 5

PhD student position in investigating the use of iPS cells for vascular anomaly (VA) research

The Translational Genomics Lab within AstraZeneca Discovery Sciences, IMED Biotech Unit, in Gothenburg, Sweden is a state-of-the-art molecular biology, cell biology and animal facility, driving cell and animal model work on the AstraZeneca Gothenburg site. Our labs are fully equipped to support molecular biology, in vitro and in vivo activities. In addition, through sister teams in the department, we have access to key equipment and skilled personnel including protein science, Next Generation Sequencing and assay development.

For the EU-MSCA-ETN project V.A. Cure, the lab invites applications for an Early Stage Researcher/PhD student position entitled:

Induced pluripotent stem (iPS) cells for vascular anomaly research related to lesions in venous malformation (VM), lymphatic malformation (LM) and arteriovenous malformation (AVM) (ESR5)

You will be part of a team of 14 ESRs working on the V.A. Cure project, which aims to uncover core mechanisms of initiation and maintenance of Vascular Anomalies with the final goal to establish novel therapeutic strategies. The project is funded in the frame of the EU MSCA-ITN programme.

Job description

You will work on a research project with the following objectives:

  • Generation of targeted VA causing mutations in human iPS cell lines and optimization of protocols for differentiation of targeted cells to iPS-ECs or iPS-LECs.
  • Generation of protocols for inducible and vascular tissue/cell type specific editing.
  • Generation of protocols for differentiated vascular cells.
  • Establish homogenous cell lines from VAs where primary cell culturing have not been successful for expansion and differentiation back to vascular cells for mechanistic studies.
  • You will also take part in the international training programme of the network and participate in various networking and outreach events.

Requirements

We are looking for a motivated student with a strong commitment to basic and/or translational research, who:

  • is eligible for MSCA-ETN funding, see here for eligibility criteria.
  • has a degree in cell biology, molecular/cell biology, biomedical sciences or related disciplines.
  • is a team player with good communication skills.

Appointment terms

The successful candidate will receive an attractive salary in accordance with MSCA regulations for Early Stage Researchers. The period of employment is 3 years. Starting date: June – October 2019.

How to apply

– Make sure you meet the qualifying requirements.

– Submit your application to: info@vacure.eu.

Please send one pdf file containing:

  • A motivation letter describing your research career goals, skills and experience (cover letter)
  • Curriculum vitae
  • Grade transcripts and BSc/MSc diploma (in English or with a translation into English)
  • Two letters of recommendation or the contact information for at least 2 referees.

Deadline for submitting applications: 22 May 2019

More information

Please visit www.vacure.eu for more information on the project, the recruitment and selection criteria. Specific questions about the position can be addressed to john.w.wiseman@astrazeneca.com by e-mail.