Individual research ESR 4

Generation and characterization of mouse models for VM and LM


Objectives:

  • Generate mouse models for VM and LM by inducible (blood, lymphatic) EC-specific expression of the causative mutation PIK3CA-H1047R
  • Characterise the cellular mechanisms of lesion formation and progression in VM/LM mouse models using microscopy techniques
  • Establish and utilise a method for detecting somatic/mosaic mutations at high sensitivity in biopsy samples to understand the contribution of mutant cells to human vascular lesions
  • Test treatment strategies and study therapy responses in VM/LM mouse models

Expected Results:

  • Establishment of genetic mouse models for VM and LM;
  • Identification of cellular changes during different stages of VM/LM lesion formation;
  • Identification of optimal dose and therapeutic time window for treatment.

Secondments: 

  • University of Oulu
  • Moleculink