Individual research ESR 7

Investigation of the mechanisms of lymphatic endothelial PIK3CA signaling during normal development and formation of lymphatic malformations


Objectives:

  • Investigate vascular development in lymphatic EC-specific gain- and loss-of-function PIK3CA mouse and zebrafish models
  • Identify PIK3CA regulated transcriptome and proteome in different types of endothelia during development and vascular lesion formation by single cell RNA sequencing and proteomics
  • Determine VM/LM specific transcriptome in comparison to AVM transcriptome

Expected Results:

  • Identification of the roles and mechanisms of action of PIK3CA in developmental lymphangiogenesis;
  • Transcriptome and proteome of ECs of normal vessels and VM/LMs; VM/LM specific transcriptome.

Secondments: 

  • Karolinska Institut
  • FinnAdvance
  • de Duve Institute