Individual research ESR 12

Respective roles of BMP9 and BMP10 in blood and lymphatic vascular homeostasis


Objectives:

  • Determine the role of BMP9 and BMP10 in early vascular development and identify genes involved in these processes in response to absence of BMP9 and/or BMP10
  • Determine the role of BMP9 and BMP10 in adult vascular homeostasis
  • Determine the role of BMP10 in heart homeostasis and metabolism
  • Determine the specificity of BMP9 in lymphatic maturation and identify genes involved in this process in response to absence of BMP9

Expected Results:

  • An understanding of the respective roles of BMP9 and BMP10 in blood and lymphatic development.
  • Identification of genes involved in angiogenesis and lymphangiogenesis.
  • Proposition of a specific therapeutic approach targeting BMP9 or BMP10 depending on their function in vascular remodelling in different territories.

Secondments:

  • University of Potsdam
  • Uppsala University
  • AstraZeneca
  • Perimed